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[11C]CURB
- Development stage
- Preclinical
- Lead developer
- Center for Addiction and Mental Health
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Reversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
[11C]CURB is a carbon-11 radiolabeled carbamate radiotracer developed for positron emission tomography (PET) imaging of fatty acid amide hydrolase (FAAH) activity in the brain. It acts as an irreversible inhibitor, selectively targeting and binding to FAAH, the primary enzyme responsible for the degradation of endocannabinoids including anandamide. [11C]CURB uptake in brain tissues demonstrates the regional distribution of FAAH, with high specificity and sensitivity, making it a reliable tool for measuring FAAH activity in vivo for research purposes, including the investigation of neuropsychiatric and neurodegenerative conditions.[1][3][5]
- Other names
- (11)C]CURB[carbonyl-11C]CURBcyclohexyl carbonic acid 3'-carbamoyl-3-yl ester
02
Targets
FAAH
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